Robert Dowling, MD

Surgical Director, Cardiac Transplantation and Mechanical Circulatory Support

Christ Hospital

Manuscripts & Publications

	Hematopoietic Stimulation During Impella 5.5 Support to Avoid Transfusions in a Jehovah’s Witness The population presenting with cardiogenic shock is heterogenous. Anemia is common in advanced heart failure and associated with poor outcomes. Microaxial flow pumps may cause ongoing blood trauma and worsen anemia.
	Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children With a Glenn Circulation Children with a bidirectional superior cavopulmonary (Glenn) circulation develop angiodysplasia and pulmonary arteriovenous malformations (AVMs). The von Willebrand factor (vWF)–angiopoietin axis plays a major role in AVM formation in multiple diseases.
	Patient-specific severity of von Willebrand factor degradation identifies patients with a left ventricular assist device at high risk for bleeding Continuous-flow left ventricular assist devices (LVADs) cause an acquired von Willebrand factor (VWF) deficiency and bleeding. Models to risk-stratify for bleeding are urgently needed. We developed a model of continuous-flow LVAD bleeding risk from patient-specific severity of VWF degradation.