History of The A-CURE Working Group

Investigations dating back to the 1960s have suggested that ventricular unloading (see “What is acute cardiac unloading”) before, during, or after the index ischemic event (heart attack) may positively affect cardiac function post-infarction.10-14 However, unloading the ventricle through either mechanical or medical means was clinically impractical. Therefore, interest in unloading was limited. However, with the development of percutaneous left ventricular support devices (pLVAD) in the early 2000’s interest in the therapeutic utility of acute ventricular unloading was invigorated.

In 2003, Meyns et al. published the first preclinical report demonstrating the effectiveness of unloading on myocardial infarct scar formation in the Journal of the American College of Cardiology.15 Over the proceeding decade, several laboratories from around the world began independent investigations into the utility of and molecular mechanisms underlying acute cardiac unloading. The developing collaborations and communication amongst these laboratories formed the foundation of the A-CURE Working Group. Since 2015 the group has convened on a biannual basis in private meetings to discuss the current efforts of the individual labs and gain insight and feedback from the member groups. The 1st Annual A-CURE Public Symposium held in Rome, Italy, on August 26th, 2016. The A-CURE Public Symposium was attended by approximately 100 clinicians, scientists, and research professionals from 21 different countries. The meeting agenda featured keynote addresses by Dr. Eugene Braunwald (Founder of the TIMI Study Group, founding editor of Braunwald’s Heart Disease)16 and Dr. Joseph Hill (Editor-in-Chief of Circulation) The 2nd Annual A-CURE Public Symposium is scheduled for August 24-25, 2017, in Barcelona, Spain. The A-CURE Faculty continues to meet on a bi-annual basis.


References Cited

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