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What Is Acute Unloading?

Dr. Douglass Mann, Washington University School of Medicine in St. Louis

Dr. Mann’s keynote address at the 2019 A-CURE Symposium on myocardial recovery and reverse remodeling.

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6th A-CURE Symposium

Best in Research Award: Tharusan Thevathasan, MD | Charité – Universitätsmedizin Berlin

Treatment with Impella and Veno-Arterial Extracorporeal Membrane Oxygenation During Cardiac Arrest Improves Survival: A Multicenter Cohort Study – Presented at A-CURE 2022.

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Videos

Dr. L. Christian Napp, Hannover Medical School

Dr. Napp speaking on how Impella-mediated ventricular unloading can be used to successfully bridge patients with Takotsubo Syndrome to recovery.

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6th A-CURE Symposium

Manreet Kanwar, MD | Allegheny Health Network

Clinical Experience of a Real World Heart Recovery Program – Presented at A-CURE 2022.

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Videos

Dr. Jason Williams, Ocean Springs Hospital

Dr. Williams discussing the use of Impella 5.0 support to optimize patient outcomes in high-risk cardiac surgery.

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6th A-CURE Symposium

Distinguished Lecture: Emma Birks, MD, PhD | University of Kentucky

Heart Recovery: Insights from RESTAGE-HF – Presented at A-CURE 2022.

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Videos

Dr. Jaime Hernandez-Montfort, UTMB Health

Dr. Hernandez-Monfort disucssing the longitudinal impact of temporary mechanical circulatory support on durable ventricular assist device outcomes.

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Videos

Dr. Bart Meyns, KU Leuven

Dr. Meyns speaking on the use of Impella support to vent VA-ECMO patients suffering from cardiogenic shock.

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6th A-CURE Symposium

Jane Wilcox, MD | Northwestern University

Patient Identification and Fundamentals of Heart Recovery vs. Remission – Presented at A-CURE 2022.

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Videos

Dr. Navin Kapur, Tufts Medical Center

Dr. Navin Kapur speaks on the relationship between acute cardiac unloading and renal function during myocardial ischemia.

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Videos

Dr. Bernhard Schieffer, University Hospital Giessen and Marburg

Dr. Schieffer speaking on how Impella support during cardiogenic shock decreases renal resistive index after myocardial infarction and prevents acute kidney injury.

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6th A-CURE Symposium

Lija Swain, PhD | Tufts Medical Center

Trans-Valvular Unloading Protects Against Myocardial Damage Before and After Reperfusion in Preclinical Models of Acute Myocardial Infarction – Presented at A-CURE 2022.

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6th A-CURE Symposium

Tomoki Sakata, MD | Mt. Sinai

Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow Improvement with Mechanical LV Unloading – Presented at A-CURE 2022.

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Videos

Dr. Carsten Tschöpe, Charite, CVK

Dr. Tschöpe discusses the use of prolonged Impella support to successfully bridge patients thru cardiogenic shock resulting from myocarditis.

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6th A-CURE Symposium

Div Verma, MD | Yavapai Regional Medical Center

Impella®-Supported MitraClip in Cardiogenic Shock Patients Complicated with MR3+/4+ – Presented at A-CURE 2022.

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6th A-CURE Symposium

David Joyce, MD | Medical College of Wisconsin

Mechanical Circulatory Support in Off-Pump CABG – Presented at A-CURE 2022.

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Videos

Dr. Alexander Bernhardt, University Hospital Hamburg-Eppendorf

Dr. Bernhardt discussing long-term support with the surgically implanted Impella 5.0 and Impella 5.5 devices.

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6th A-CURE Symposium

Enrico Romagnoli, MD | Gemelli University Hospital

Wall Motion Score Index (WMSI) in Revascularization and Ventricular Recovery – Presented at A-CURE 2022.

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Videos

Dr. Bill O’Neill, Henry Ford Hospital

Dr. O’Neill speaking on the improved survival of AMI cardiogenic shock patients in the National Cardiogenic Shock Initiative resulting from the early deployment of Impella support prior to reperfusion.

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6th A-CURE Symposium

Peter Frederiksen, MD | University of Southern Denmark

LV Strain under Impella RP Support in a Swine Model of Cardiogenic Shock – Presented at A-CURE 2022.

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6th A-CURE Symposium

Sebastian Billig, MD | University Hospital Aachen

Promising First Results of a New Developed Percutaneous Left Ventricular Assist Device in a Large Animal Model of Cardiac Arrest – Presented at A-CURE 2022.

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Videos

Dr. Dan Burkhoff, Columbia University

Dr. Burkhoff speaks on the use of the novel PreCardia device to acute unload and support patients presenting with acute decompensated heart failure.

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6th A-CURE Symposium

Opening Lecture: Dan Burkhoff, MD | Columbia University

Annual Update: The State of the Field in Cardiac Unloading – Presented at A-CURE 2022

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5th A-CURE Symposium

Bill O’Neill, MD | Henry Ford Health System

Update from the National Cardiogenic Shock Initiative – Presented at A-CURE 2020.

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5th A-CURE Symposium

Bob Kloner | Huntington Medical Research Institute & Kiyo Ishikawa | Icahn School of Medicine

Bob Kloner (Huntington Medical Research Institute), Investigating Treatment with Therapeutic Hypothermia for Ischemia of the Heart & Kiyo Ishikawa (Icahn School of Medicine Mt. Sinai) Mechanical Left Ventricular Unloading and Therapeutic Hypothermia – Presented at A-CURE 2020.

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5th A-CURE Symposium

Elric Zweck | Heinrich-Heine University, Dusseldorf

Identification of Three Phenotypes of Cardiogenic Shock – Presented at A-CURE 2020.

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5th A-CURE Symposium

Herman Reichenspurner | University Hospital Hamburg-Eppendorf

Impella 5.5® as an Ideal Bridge to Left Ventricular Assist Device – Presented at A-CURE 2020.

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Videos

Prof. Dr. med. Carsten Tschöpe, Charité, CVK Ventricular Unloading and Inflammation - The Role of Impella in Myocarditis

Dr. Tschöpe speaking on how he used Impella support to bridge a patient through myocarditis.

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5th A-CURE Symposium

Mark Anderson | Hackensack Meridian School of Medicine

A New Strategy for the Treatment of Patients with Type 1 Cardiorenal Syndrome with Impella® – Presented at A-CURE 2020.

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5th A-CURE Symposium

Navin Kapur | Tufts Medical Center

A New Role for Circulatory Support Devices to Limit Ischemia-Reperfusion Injury – Presented at A-CURE 2020.

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5th A-CURE Symposium

Zach George | University of South Carolina

ST-Segment Elevation MI-Door-to-Unload (STEMI-DTU) Trial Updates – Presented at A-CURE 2020.

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5th A-CURE Symposium

Dan Burkhoff | Columbia

The State of the Field: Our Current Understanding of Ventricular Unloading – Presented at A-CURE 2020.

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5th A-CURE Symposium

Jakob Josiassen | Copenhagen University Hospital: Abstract Finalist

Impella RP® vs. Pharmacological Vasoactive Treatment in Profound Cardiogenic Shock Due to Acute Ischemic Occlusion of the Right Coronary Artery: Ventricular Unloading and End-Organ Perfusion in a Large Animal Model – Presented at A-CURE 2020.

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5th A-CURE Symposium

Kay Everett | Beth Israel Deaconess Medical Center: Abstract Finalist

Acute Hemodynamic Effects of Pre-Emptive Impella® Unloading Before Venoarterial Extracorporeal Membrane Oxygenation in a Preclinical Model of Acute MI – Presented at A-CURE 2020.

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5th A-CURE Symposium

Lija Swain | Tufts Medical Center: Abstract Finalist

Left Ventricular Unloading Protects Against Both Ischemia and Reperfusion Injury – Presented at A-CURE 2020.

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Videos

Dr. Babar Basir, Henry Ford Hospital

Dr. Babar Basir speaking on improving clinical outcomes by applying a new algorithm for patient selection in the Detroit Cardiogenic Shock Initiative

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Videos

Dr. Kiyotake Ishikawa, Icahn School of Medicine at Mount Sinai

Left ventricular unloading leading to unloading of the left atria, and subsequent inhibition of atrial arrhythmia due to decrease atrial wall stress.

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Videos

Dr. Mark Anderson, Hackensack University Medical Center

Dr. Mark Anderson speaking the clinical experience and data of the novel right ventricular support device, Impella RP.

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Videos

Dr. Kapildeo Lotun, University of Arizona

Dr. Kapildeo Lotun on the use of Impella support during cardiac arrest in the catheterization lab to bridge patients to recovery

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Videos

Dr. Daniel Scheiber, University Hospital Dusseldorf

Dr. Daniel Scheiber speaking on the effects of long-term ventricular unloading on myocardial mitochondrial ROS production.

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What Is Acute Unloading?

Dr. Ralf Westenfeld, University Hospital Dusseldorf

Impella support improves pulmonary congestion in patients treated for cardiogenic shock

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Videos

Dr. Elazer Edelman, MIT & Harvard University

Dr. Edelman at the the 2017 A-CURE Symposium speaking on device-based approaches to monitor cardiac function of patients on Impella support.

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What Is Acute Unloading?

Dr. Carlos del Rio, MyoKardia and QTest Labs

The Paradoxical Energetic Energetic Costs of Acute Mechanical Unloading

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What Is Acute Unloading?

Dr. Jacob Moller, University of Odense Denmark

Comparative hemodynamics of ECMO and Impella support in a model of cardiogenic shock

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Videos

Derek Hausenloy, MD, PhD, Duke National University Singapore Reducing Myocardial Infarct Size: Translational Challenges and Opportunities

Dr. Hausenloy provides insights into translational opportunities in the field of ischemia reperfusion injury at the 2016 A-CURE Symposium.

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Videos

Dan Burkhoff, MD, PhD, Columbia University Perspective on Acute Unloading

Dan Burkhoff speaks on the hemodynamics of acute unloading and the important clinical implications at A-CURE 2017.

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6th A-CURE Symposium

Innovation Lecture: Navin Kapur, MD | Tufts Medical Center

Current Understanding of the Molecular Mechanisms of Unloading & Recovery: Past, Present, and Future – Presented at A-CURE 2022.

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6th A-CURE Symposium

Nicolas Brozzi, MD | Cleveland Clinic Florida

High-Risk Non-Cardiac Surgery: Successful Bridging of Morbidly Obese Patients to HTx – Presented at A-CURE 2022

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6th A-CURE Symposium

Kay Everett, MD, PhD | Tufts Medical Center

Combining VA-ECMO and Impella (EC-Pella) Before Reperfusion Mitigates Left Ventricular Injury Due to VA-ECMO in Acute Myocardial Infarction – Presented at A-CURE 2022

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6th A-CURE Symposium

Ed Soltesz, MD | Cleveland Clinic

Mechanical Circulatory Support in High-Risk CABG – Presented at A-CURE 2022.

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6th A-CURE Symposium

Keynote Lecture: Clyde Yancy, MD | Northwestern University

The Treatment of Stage D Heart Failure: Devices, Drugs, Biology, and Genes – Evidence and Guidelines – Presented at A-CURE 2022.

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6th A-CURE Symposium

Young Investigator Award: Renata Mazurek, MD | Mt. Sinai

Negative Effects of Acute Reloading after Mechanical Left Ventricle Unloading for Acute Myocardial Infarction in a Pig Model – Presented at A-CURE 2022.

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What Is Acute Unloading?

Dr. Dan Burkhoff, Columbia University

Dr. Daniel Scheiber speaking at the 2019 A-CURE Symposium on the state of the field of unloading research.

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Videos

Dr. Howard Chen, Tufts University Medical Center

Dr. Chen speaking on the detection autophagy in myocardial I/R injury and the impact of Impella-mediate ventricular unloading.

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Videos

Dr. Lija Swain, Tufts University Medical Center

Dr. Swain speaking on the effect of acute ventricular unloading during myocardial ischemia on mitochondrial function.

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Videos

Dr. Nanna Udesen, Odense University Hospital

Dr. Udeson speaking on her pre-clinical investigations on the effect of concomitant vasoactive treatments combined with mechanical support on left ventricular function and end organ perfusion.

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Videos

Dr. Kiyotake Ishikawa, Mt. Sinai Hospital

Dr. Ishikawa speaking on improving cardiac gene therapy efficacy by using the Impella mechanical circulatory pump.

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6th A-CURE Symposium

Andreas Schäfer, MD | Hannover Medical Center

Complete Revascularization and Acute Unloading Prior to PCI Increases Survival in AMI-CGS – Presented at A-CURE 2022.

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Videos

Dr. Heimo Ehmke, Univeristy Center Hamburg-Eppendorf

Dr. Ehmke presenting his preclinical data investigating how cardiac unloading reverses infarction-induced changes in gene expression.

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6th A-CURE Symposium

Carsten Tschöpe, MD | Charité – Universitätsmedizin Berlin

Effect of Ventricular Unloading on Heart Recovery – Presented at A-CURE 2022.

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Videos

Dr. Daniel Burkhoff, MD, PhD Columbia University The Science Behind Acute Ventricular and Myocardial Unloading

Dr. Dan Burkhoff speaking on the science behind acute ventricular unloading and myocardial recovery at the 2016
A-CURE Symposium.

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