Note: Topics and session time may update.

November 3, 2022

Chicago Willis Tower

99th Floor, 233 S Wacker Dr.
Chicago, IL 60606

6:00 - 8:00 p.m.

Welcome and Networking Dinner

Pre-conference cocktail reception and dinner with A-CURE faculty and attendees
RSVP only by registration or by emailing info@a-cure.org

November 4, 2022

Chicago Athletic Association Hotel

In-person:
12 S. Michigan Ave
Chicago, IL

Virtual: Access link will be provided to registered attendees via email
All meeting times are Central Daylight Time (UTC-5)

7:00-8:00 a.m.

Breakfast & Check-in

Check-in Location: 8th Floor Lobby
Breakfast Location: White City Ballroom
Symposium: Madison Ballroom

8:00 a.m.

Welcome and Introductory Comments

8:00-8:15 a.m.

Opening Lecture
Dan Burkhoff, MD, PhD (Cardiovascular Research Foundation)

The State of the Field in Cardiac Unloading: Annual Update

Session I

Advances in Basic and Preclinical Science of Acute Unloading and Myocardial Recovery

8:15-9:15 a.m.

Discussion leaders: Kiyotake Ishikawa, MD, PhD (Mt. Sinai) & Patrick Hunziker, MD (Univ. Hospital Basel)

8:15-8:30 a.m.

Bart Meyns, MD, PhD (KU Leuven)

Topic: Reverse Remodeling in an Ovine Model of Ischemic Cardiomyopathy

8:30-8:45 a.m.

Steve Keller, MD, PhD, MPhil (Johns Hopkins Univ.)

Topic: Cardiac State Optimization to Promote Recovery during Extracorporeal Circulatory Support

8:45-9:00 a.m.

Abstract: Peter Frederiksen, MD (Odense Univ. Hospital)

Topic: Cardiac Energetics and Systemic Perfusion with Veno-arterial ECMO versus Ecmella for Cardiogenic Shock in a Large Animal Model
*Presented by Ann Banke, MD, PhD (Odense Univ. Hospital)

9:00-9:15 a.m.

Abstract: Spyros Mavropoulos, MD, PhD (Mt. Sinai)

Topic: An Analysis of Extracellular Matrix Proteins Involved in the Loaded and Unloaded Heart after Myocardial Infarction

Keynote Lecture

9:15-10:00 a.m.

Biykem Bozkurt, MD, PhD
(Editor-in-Chief, JACC: HF; Baylor College of Medicine)

Topic: Decompensated Heart Failure, Taking the Acute out of Decompensation

Introduction: Bobbi Bogaev Chapman, MD

10:00-10:15 a.m.

Break

Session II

Clinical Science and Evidence for Cardiac Unloading & Recovery

10:15-11:30 a.m.

Discussion leaders: Claudius Mahr, DO (Univ.of Washington) & Jacob Møller, MD (Odense Univ. Hospital)

10:15-10:30 a.m.

William O’Neill, MD (Henry Ford Hospital)

Topic: Impact of CMR-derived Infarct Size on LV Remodeling: the Roll-in DTU Experience

10:30-10:45 a.m.

Navin Kapur, MD (Tufts Medical Center)

Topic: Delaying Reperfusion for Thirty Minutes in the Presence of Active LV Unloading Reduces Infarct Size in Anterior STEMI: A Per Protocol Analysis of the STEMI Door to Unload (DTU) Pilot Study

10:45-11:00 a.m.

Ralf Westenfeld, MD (Univ. Düsseldorf)

Topic: PROTECT Kidney Randomized Controlled Trial – MRI Pilot Study

11:00-11:15 a.m.

Paul Haller, MD (UKE Hamburg)

Topic: Automatic LV Unloading using a Percutaneous Transvalvular Microaxial Flow Pump during VA-ECMO Support
*Presented by: Benedikt Schrage, MD (UKE Hamburg)

11:15-11:30 a.m.

Christian Moyer, PhD (Abiomed, Inc)

Topic: Smarter Pumps: Measuring Cardiac Function with Impella Signals

11:30-11:45 a.m.

Break

Session III

Emerging Trials In Clinical Applications of Cardiac Unloading

11:45-12:30 p.m.

Discussion leaders: Andreas Schäfer, MD (Hannover Medical Center) and Carsten Tschöpe, MD (Charité – Univ. Berlin)

11:45-12:00 p.m.

Benedikt Schrage, MD (UKE Hamburg)

Topic: Unload-ECMO Randomized Controlled Trial for LV Unloading with VA-ECMO in Severe Cardiogenic Shock

12:00-12:15 p.m.

Mir Babar Basir, DO (Henry Ford Hospital)

Topic: CERAMICS: Best Practices for MCS Escalation and Management in AMI-CS

12:15-12:30 p.m.

Alex Nap, MD, PharmD, PhD (UMC Amsterdam)

Topic: UNLOAD-HF Randomized Controlled Trial for LV Unloading in Acute Heart Failure

Live Poster Session
12:30-2:00 p.m.
Location: White City Ballroom

Lunch will be served

Awards Announcements: Navin Kapur, MD (Tufts Medical Center) and Kenji Sunagawa, MD, PhD (Kyushu University)

2:00-2:15 p.m.

Young Investigator Award
Lija Swain, PhD (Tufts Medical Center)

Topic: Trans-Valvular Unloading Reduces Anaerobic Glycolysis before Reperfusion and Preserves Energy Substrate Utilization after Reperfusion in Models of Acute Myocardial Infarction

2:15-2:30 p.m.

Best in Research Award
Tomoki Sakata, MD, PhD (Mt. Sinai)

Topic: Mechanical LV Unloading Increases Coronary Flow by Prolonging Diastolic Phase

2:30-2:55 p.m.

Panel Discussion
Topic: Targeting Heart Recovery in a Real-World Setting

Panelists:
Manreet Kanwar, MD (Allegheny General Hospital)
Jane Wilcox, MD (Northwestern Medicine)
Bart Meyns, PhD (UZ Leuven)

Moderator:
Bobbi Bogaev Chapman, MD

2:55-3:15 p.m.

Break

Session IV

Frontiers in Surgical and Clinical Applications of Unloading

3:15-5:00 p.m.

Discussion leader: Mark Anderson, MD (Hackensack Meridian)

3:15-3:30 p.m.

Abstract: Alessandro Beneduce, MD (IRCCS San Raffaele)

Topic: A Novel Fluoroscopic Approach to Impella Percutaneous Ventricular Assist Device Positioning
*Presented by Luca Baldetti, MD, (IRCCS San Raffaele)

3:30-3:45 p.m.

Abstract: Kay Everett, MD, PhD (Tufts Medical Center)

Topic: Left Ventricular Unloading Acutely Reduces Right Ventricular Preload in Patients with Acute Decompensated Heart Failure and Cardiogenic Shock

3:45-4:00 p.m.

Ryan Tedford, MD (Medical College of South Carolina)

Topic: The Role of RV Reserve Assessment and LV Unloading to Predict Right Heart Failure after LVAD Implantation

4:00-4:25 p.m.

Panel Discussion
Topic: Advanced Surgical Uses of PVAD Support and Patient Management

Moderator:
Mark Anderson, MD (Hackensack Meridian Health)

Brief case presentation:
Hermann Reichenspurner, MD (UKE Hamburg)
Alexander Bernhardt, MD (UKE Hamburg)

Panelists:
Hermann Reichenspurner, MD, PhD (UKE Hamburg)
Alexander Bernhardt, MD (UKE Hamburg)

4:25-4:55 p.m.

Panel Discussion
Topic: Non-Cardiac Surgery Interventions on Patients Receiving Impella Support

Panelists:
Nicolas Brozzi, MD (Cleveland Clinic Florida)
Raul Rosenthal, MD (Cleveland Clinic Florida)
Jaime Hernandez-Montfort, MD (Baylor Scott & White Health)
Ramachandra Reddy, MD (Baylor Scott & White Health)
Modesto J. Colón, MD (Banner Univ. Medical Center)
Radha S. Gopalan, MD (Banner Univ. Medical Center)

4:55-5:00 p.m.

Session Closing

5:00 p.m.

Closing Comments, Audience Feedback, and Adjourn

Topics: How to Claim CME Credit / Evaluation Form

5:00-7:00 p.m.

Cocktail Reception & Poster Viewing
Location: White City Ballroom

Note: Topics and session time may update.