Note: Topics and session time may update.

November 3, 2022

Chicago Willis Tower

233 S Wacker Dr.
Chicago, IL 60606

6:00 - 8:00 p.m.

Welcome and Networking Dinner

Pre-conference cocktail reception and dinner with A-CURE faculty and attendees
RSVP only by registration or by emailing info@a-cure.org

November 4, 2022

Chicago Athletic Association Hotel

In-person:
12 S. Michigan Ave
Chicago, IL

Virtual: Access link will be provided to registered attendees via email
All meeting times are Central Daylight Time (UTC-5)

7:00-8:00 a.m.

Breakfast & Check-in

Check-in Location: Madison Ballroom
Breakfast Location: White City Ballroom

8:00 a.m.

Welcome and Introductory Comments & Opening Video

8:00-8:20 a.m.

Opening Lecture
Dan Burkhoff, MD, PhD (Cardiovascular Research Foundation)

Annual Update: The State of the Field in Cardiac Unloading

Session I

Advances in Basic and Preclinical Science of Acute Unloading and Myocardial Recovery

8:20-9:50 a.m.

Discussion leaders: Kiyotake Ishikawa, MD, PhD (Mt. Sinai) & Patrick Hunziker, MD (University Hospital Basel)

8:20-8:35 a.m.

Bart Meyns, MD (KU Leuven)

Topic: LV Unloading and Reverse Remodeling in an Ovine Model of Ischemic Cardiomyopathy

8:35-8:50 a.m.

Steve Keller, MD, PhD (Johns Hopkins)

Topic: Hybrid Flows in ECMO+IABP vs ECMO+Impella in a Swine model of Cardiogenic Shock

8:50-9:05 a.m.

Abstract: Peter Frederiksen, MD (Odense University Hospital)

Topic: Cardiac Energetics and Systemic Perfusion with Veno-arterial ECMO versus Ecmella for Cardiogenic Shock in a Large Animal Model
*Presented by Ann Banke, MD, PhD (Odense University Hospital)

9:05-9:20 a.m.

Abstract: Spyros Mavropoulos, MD, PhD (Mt. Sinai)

Topic: An Analysis of Extracellular Matrix Proteins Involved in the Loaded and Unloaded Heart After Myocardial Infarction

Award Announcement: Kenji Sunagawa, MD, PhD (Kyushu University)

9:20-9:35 a.m.

Young Investigator Award
Lija Swain, PhD (Tufts Medical Center)

Topic: Trans-valvular Unloading Reduces Anaerobic Glycolysis before Reperfusion and Preserves Energy Substrate Utilization after Reperfusion in Models of Acute MI

9:35-9:50 a.m.

Best in Research Award
Tomoki Sakata, MD, PhD (Mt. Sinai)

Topic: Mechanical LV Unloading Increases Coronary Flow by Prolonging Diastolic Phase

9:50-9:55 a.m.

Session I – Open Floor Q&A

9:55-10:15 a.m.

Break

Session II

Clinical Science and Evidence for Cardiac Unloading and Recovery

10:15-12:00 p.m.

On-going Trials
Discussion leaders: Claudius Mahr, DO (University of Washington) & Jacob Moller, MD (Odense University Hospital)

10:15-10:30 a.m.

William O’Neill, MD (Henry Ford Hospital)

Topic: Impact of CMR-derived Infarct Size on LV Remodeling: the Roll-in DTU Experience

10:30-10:45 a.m.

Navin Kapur, MD (Tufts Medical Center)

Topic: Delaying Reperfusion for Thirty Minutes in the Presence of Active LV Unloading Reduces Infarct Size in Anterior STEMI: A Per Protocol Analysis of the STEMI Door to Unload (DTU) Pilot Study

10:45-11:00 a.m.

Ralf Westenfeld, MD (Univ. Dusseldorf)

Topic: PROTECT Kidney Randomized Controlled Trial – BOLD-MRI Pilot Study

11:00-11:15 a.m.

Paul Haller, MD (UKE Hamburg)

Topic: Flow Modulation in Combined Impella and VA-ECMO (ECpella) Use in Cardiogenic Shock
*Presented by: Benedikt Schrage, MD (UKE Hamburg)

11:15-11:25 a.m.

Break

Emerging Trials
Discussion leaders: Andreas Schafer, MD (Hannover Medical Center) & Carsten Tschope, MD (Charite Berlin)

11:15-11:40 a.m.

Benedikt Schrage, MD (UKE Hamburg)

Topic: UNLOAD-ECMO Randomized Controlled Trial for LV Unloading with VA-ECMO in Cardiogenic Shock

11:40-11:55 a.m.

Mir Babar Basir, DO (Henry Ford Hospital)

Topic: CERAMICS – Best Practices for MCS Escalation and Management in AMI-Cardiogenic Shock

11:55-12:10 p.m.

Alex Nap, MD (UMC Amsterdam)

Topic: UNLOAD-HF Randomized Controlled Trial for LV Unloading in Acute Heart Failure

12:10-12:50 p.m.

Lunch Break
Location: White City Ballroom

Live Poster Session
12:50-1:50 p.m.
Poster Location: White City Ballroom

Virtual: Access link will be provided to registered attendees via email

Keynote Lecture

1:50-2:30 p.m.

Biykem Bozkurt, MD, PhD
(Editor-in-Chief, JACC:Heart Failure; Baylor College of Medicine)

Topic: Decompensated Heart Failure, Taking the Acute out of Decompensation

Introduction: Jeffery Moses, MD (Columbia University)

2:30-2:55 p.m.

Panel Discussion
Topic: Targeting Heart Recovery in a Real-World Setting

Panelists:
Manreet Kanwar, MD (Allegheny General Hospital)
Jane Wilcox, MD (Northwestern Medicine)
Biykem Bozkurt, MD, PhD (Baylor College of Medicine)

Moderator:
Bobbi Bogaev Chapman, MD (Abiomed)

2:55-3:15 p.m.

Break

Session III

Frontiers in Surgical and Clinical Applications of Unloading

3:15-5:00 p.m.

Discussion leaders: Rob Dowling, MD (Christ Hospital) & Mark Anderson, MD (Hackensack Meridian)

3:15-3:30 p.m.

Abstract: Alessandro Beneduce, MD (IRCCS San Raffaele)

Topic: A Novel Fluoroscopic Approach to Impella Percutaneous Ventricular Assist Device Positioning

3:30-3:45 p.m.

Abstract: Kay Everett, MD, PhD (Tufts Medical Center)

Topic: Left Ventricular Unloading Acutely Reduces Right Ventricular Preload in Patients with Acute Decompensated Heart Failure and Cardiogenic Shock

3:45-4:00 p.m.

Ryan Tedford, MD (Medical College of South Carolina)

Topic: The Role of RV Reserve Assessment and LV Unloading to Predict Right Heart Failure after LVAD Implantation

4:00-4:25 p.m.

Panel Discussion
Topic: pVAD Bridging and Optimization before durable LVAD Implantation and Heart Transplant

Panelists:
Hermann Reichenspurner, MD (UKE Hamburg)
Alexander Bernhardt, MD (UKE Hamburg)
Robert Dowling, MD (Christ Hospital)
Mark Anderson, MD (Hackensack Meridian Health) - Moderator

4:25-4:50 p.m.

Panel Discussion
Topic: Non-Cardiac Surgery Interventions on Patients Receiving Impella Support

Panelists:
Experience at Cleveland Clinic Florida
Nicolas Brozzi, MD (Cleveland Clinic Florida)
Raul Rosenthal, MD (Cleveland Clinic Florida)

Experience at Baylor System
Jaime Hernandez-Montfort, MD (Baylor Scott & White Health)
Ramachandra Reddy, MD (Baylor Scott & White Health)

4:50-5:00 p.m.

Session III – Open Floor Q&A

5:00 p.m.

Closing Comments, Audience Feedback, and Adjourn

[How to claim CME Credits]

5:00-7:00 p.m.

Cocktail Reception & Poster Viewing
Location: White City Ballroom (In-Person Only)

Network with the A-CURE Faculty, Speakers, and the Attendees

Note: Topics and session time may update.