Note: Topics and session time may update.

November 3, 2022

Chicago Willis Tower

233 S Wacker Dr.
Chicago, IL 60606

6:00 - 8:00 p.m.

Welcome and Networking Dinner

Pre-conference cocktail reception and dinner with A-CURE faculty and attendees
RSVP only by registration or by emailing

November 4, 2022

Chicago Athletic Association Hotel

12 S. Michigan Ave
Chicago, IL

Virtual: Access link will be provided to registered attendees via email
All meeting times are Central Daylight Time (UTC-5)

7:00-8:00 a.m.

Breakfast & Check-in

Check-in Location: Madison Ballroom
Breakfast Location: White City Ballroom

8:00 a.m.

Welcome and Introductory Comments & Opening Video

8:00-8:20 a.m.

Opening Lecture
Dan Burkhoff, MD, PhD (Cardiovascular Research Foundation)

Annual Update: The State of the Field in Cardiac Unloading

Session I

Advances in Basic and Preclinical Science of Acute Unloading and Myocardial Recovery

8:20-9:50 a.m.

Discussion leaders: Kiyotake Ishikawa, MD, PhD (Mt. Sinai) & Patrick Hunziker, MD (University Hospital Basel)

8:20-8:35 a.m.

Bart Meyns, MD (KU Leuven)

Topic: LV Unloading and Reverse Remodeling in an Ovine Model of Ischemic Cardiomyopathy

8:35-8:50 a.m.

Steve Keller, MD, PhD (Johns Hopkins)

Topic: Hybrid Flows in ECMO+IABP vs ECMO+Impella in a Swine model of Cardiogenic Shock

8:50-9:05 a.m.

Abstract: Peter Frederiksen, MD (Odense University Hospital)

Topic: Cardiac Energetics and Systemic Perfusion with Veno-arterial ECMO versus Ecmella for Cardiogenic Shock in a Large Animal Model
*Presented by Ann Banke, MD, PhD (Odense University Hospital)

9:05-9:20 a.m.

Abstract: Spyros Mavropoulos, MD, PhD (Mt. Sinai)

Topic: An Analysis of Extracellular Matrix Proteins Involved in the Loaded and Unloaded Heart After Myocardial Infarction

Award Announcement: Kenji Sunagawa, MD, PhD (Kyushu University)

9:20-9:35 a.m.

Young Investigator Award
Lija Swain, PhD (Tufts Medical Center)

Topic: Trans-valvular Unloading Reduces Anaerobic Glycolysis before Reperfusion and Preserves Energy Substrate Utilization after Reperfusion in Models of Acute MI

9:35-9:50 a.m.

Best in Research Award
Tomoki Sakata, MD, PhD (Mt. Sinai)

Topic: Mechanical LV Unloading Increases Coronary Flow by Prolonging Diastolic Phase

9:50-9:55 a.m.

Session I – Open Floor Q&A

9:55-10:15 a.m.


Session II

Clinical Science and Evidence for Cardiac Unloading and Recovery

10:15-12:00 p.m.

On-going Trials
Discussion leaders: Claudius Mahr, DO (University of Washington) & Jacob Moller, MD (Odense University Hospital)

10:15-10:30 a.m.

William O’Neill, MD (Henry Ford Hospital)

Topic: Impact of CMR-derived Infarct Size on LV Remodeling: the Roll-in DTU Experience

10:30-10:45 a.m.

Navin Kapur, MD (Tufts Medical Center)

Topic: Delaying Reperfusion for Thirty Minutes in the Presence of Active LV Unloading Reduces Infarct Size in Anterior STEMI: A Per Protocol Analysis of the STEMI Door to Unload (DTU) Pilot Study

10:45-11:00 a.m.

Ralf Westenfeld, MD (Univ. Dusseldorf)

Topic: PROTECT Kidney Randomized Controlled Trial – BOLD-MRI Pilot Study

11:00-11:15 a.m.

Paul Haller, MD (UKE Hamburg)

Topic: Flow Modulation in Combined Impella and VA-ECMO (ECpella) Use in Cardiogenic Shock
*Presented by: Benedikt Schrage, MD (UKE Hamburg)

11:15-11:25 a.m.


Emerging Trials
Discussion leaders: Andreas Schafer, MD (Hannover Medical Center) & Carsten Tschope, MD (Charite Berlin)

11:15-11:40 a.m.

Benedikt Schrage, MD (UKE Hamburg)

Topic: UNLOAD-ECMO Randomized Controlled Trial for LV Unloading with VA-ECMO in Cardiogenic Shock

11:40-11:55 a.m.

Mir Babar Basir, DO (Henry Ford Hospital)

Topic: CERAMICS – Best Practices for MCS Escalation and Management in AMI-Cardiogenic Shock

11:55-12:10 p.m.

Alex Nap, MD (UMC Amsterdam)

Topic: UNLOAD-HF Randomized Controlled Trial for LV Unloading in Acute Heart Failure

12:10-12:50 p.m.

Lunch Break
Location: White City Ballroom

Live Poster Session
12:50-1:50 p.m.
Poster Location: White City Ballroom

Virtual: Access link will be provided to registered attendees via email

Keynote Lecture

1:50-2:30 p.m.

Biykem Bozkurt, MD, PhD
(Editor-in-Chief, JACC:Heart Failure; Baylor College of Medicine)

Topic: Decompensated Heart Failure, Taking the Acute out of Decompensation

Introduction: Jeffery Moses, MD (Columbia University)

2:30-2:55 p.m.

Panel Discussion
Topic: Targeting Heart Recovery in a Real-World Setting

Manreet Kanwar, MD (Allegheny General Hospital)
Jane Wilcox, MD (Northwestern Medicine)
Biykem Bozkurt, MD, PhD (Baylor College of Medicine)

Bobbi Bogaev Chapman, MD (Abiomed)

2:55-3:15 p.m.


Session III

Frontiers in Surgical and Clinical Applications of Unloading

3:15-5:00 p.m.

Discussion leaders: Rob Dowling, MD (Christ Hospital) & Mark Anderson, MD (Hackensack Meridian)

3:15-3:30 p.m.

Abstract: Alessandro Beneduce, MD (IRCCS San Raffaele)

Topic: A Novel Fluoroscopic Approach to Impella Percutaneous Ventricular Assist Device Positioning

3:30-3:45 p.m.

Abstract: Kay Everett, MD, PhD (Tufts Medical Center)

Topic: Left Ventricular Unloading Acutely Reduces Right Ventricular Preload in Patients with Acute Decompensated Heart Failure and Cardiogenic Shock

3:45-4:00 p.m.

Ryan Tedford, MD (Medical College of South Carolina)

Topic: The Role of RV Reserve Assessment and LV Unloading to Predict Right Heart Failure after LVAD Implantation

4:00-4:25 p.m.

Panel Discussion
Topic: pVAD Bridging and Optimization before durable LVAD Implantation and Heart Transplant

Hermann Reichenspurner, MD (UKE Hamburg)
Alexander Bernhardt, MD (UKE Hamburg)
Robert Dowling, MD (Christ Hospital)
Mark Anderson, MD (Hackensack Meridian Health) - Moderator

4:25-4:50 p.m.

Panel Discussion
Topic: Non-Cardiac Surgery Interventions on Patients Receiving Impella Support

Experience at Cleveland Clinic Florida
Nicolas Brozzi, MD (Cleveland Clinic Florida)
Raul Rosenthal, MD (Cleveland Clinic Florida)

Experience at Baylor System
Jaime Hernandez-Montfort, MD (Baylor Scott & White Health)
Ramachandra Reddy, MD (Baylor Scott & White Health)

4:50-5:00 p.m.

Session III – Open Floor Q&A

5:00 p.m.

Closing Comments, Audience Feedback, and Adjourn

[How to claim CME Credits]

5:00-7:00 p.m.

Cocktail Reception & Poster Viewing
Location: White City Ballroom (In-Person Only)

Network with the A-CURE Faculty, Speakers, and the Attendees

Note: Topics and session time may update.