The A-CURE Faculty and network of colleagues are on the front lines of treating COVID-19 patients within hospital systems. The data on treatment and outcomes in these patients is fluid and rapidly evolving.

Current data indicate that 7-16% of COVID-19 patients experience cardiac complications or acute cardiac injury (Link to JACC paper). Further, reports indicate that mortality exceeds 10% in patients with underlying cardiovascular disease.

Worldwide, we along with our industry partners understand that some COVID-19 patients are currently being supported with mechanical circulatory support.

In this turbulent environment, there is no clear treatment modality for these patients and the open exchange of data and

experiences will be critical to optimizing patient outcomes.

To facilitate an open exchange, the A-CURE Faculty have established this website section to disseminate the rapidly evolving information available regarding patients in which mechanical support and acute ventricular unloading may be of use. We will exchange clinical data, basic research, and case studies which may help inform decision making to treat.

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Welcome!
Acute Cardiac Unloading and REcovery Working Group

Join us as we move the science of ventricular unloading forward!

Highlights from the 2019 4th Annual A-CURE Symposium Paris

Watch Douglas Mann, MD, give the Keynote Address at the 2019 A-CURE Symposium

Read the Interventional Cardiology Review proceedings of the 2019 A-CURE Symposium

Click to be taken to ICR

Explore the science and history behind acute unloading

Use our Resources library to and explore peer-reviewed publication, educational tools, and talks from our Faculty members on acute cardiac unloading.

Access Resource Library

The A-CURE Working Group is comprised of leading academic experts in clinical and basic cardiac research that is dedicated to advancing the science and clinical application of acute cardiac unloading.

Featured Resources

Journal of Cardiovascular Transnational Research

In this issue of the Journal of Cardiovascular and Translational Research (JCTR) 10 articles focused on new and emerging topics in the field of mechanical unloading are presented including state-of-the-art reviews and new primary pre-clinical and clinical reports.

Circulation Heart Failure, May 2018

Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs

JACC, 2018

Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarct

View the Latest A-CURE Resources & Publications

Access current publications, abstracts, experimental protocols, and other valuable resources.

Start using the Harvi app today!

Learn cardiovascular physiology, hemodynamics, and pressure-volume loops through this dynamic, interactive simulation.

Have a Question About Acute Cardiac Unloading?

Email the A-CURE Working Group faculty to inquire about the science of unloading, experimental protocols, potential collaborations, or other questions on acute unloading.

Understanding the Pressure-Volume Loop

The pressure-volume loop is an excellent way of understanding the science of acute unloading. This video series presented by Khan Academy provides a first-rate source for educating yourself and your students on the hemodynamic information contained in the P-V loop.

Watch more videos on understanding the pressure-volume loop relationship in the heart

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Search the TCT 2019 Scientific Sessions for A-CURE Faculty members!

TCT 2019 Scientific Sessions

September 25-29, 2019
San Francisco, California